The Alaska Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. Serving the state of Alaska, it is a partnership of SERRC - Alaska's Educational Resource Center, the Northwest Regional Educational Laboratory (Northwest REL), and the Alaska Department of Education and Early Development.

The Appalachia Regional Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. It serves the states of Kentucky, North Carolina, Tennessee, Virginia and West Virginia. It is operated by Edvantia in partnership with the Center for Equity and Excellence in Education at George Washington University, the Eastern Stream Center on Resources and Training (ESCORT), the National Center for Family Literacy, the SERVE Center for Continuous Improvement at the University of North Carolina—Greensboro, and the Southern Regional Education Board, the National Center for Family Literacy.

The Assessment and Accountability Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. The Center helps states and districts with the knowledge and skills to fully implement, evaluate, and improve their assessment and accountability systems in order to reach the overarching No Child Left Behind goal of academic proficiency for all students. The Center is operated by WestEd and the National Center for Researcch on Evaluation, Standards and Student Testing.

The California Comprehensive Center is one of 21 comprehensive centers funded by U.S. Department of Education. It serves the state of California. It is operated by WestEd in partnership with American Institutes for Research and School Services of California.

The Center on Innovation and Improvement is one of 21 comprehensive centers funded by the U.S. Department of Education. The Center helps states and districts provide teachers and parents with the opportunity, information, and skills to make wise decisions on behalf of students. The Center administered by the Academic Development Institute in collaboration with its partners, Temple University Center for Research in Human Development and Education and Little Planet Learning.

The Center on Instruction is one of 21 comprehensive centers funded by the U.S. Department of Education. The Center on Instruction, a partnership of five organizations, provides resources and expertise to the Regional Comprehensive Centers in reading, mathematics, science, special education, and English language learners. The RMC Research Corporation oversees the partnership.

The Florida and the Islands Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. It serves the state of Florida, Puerto Rico, and the U.S. Virgin Islands. It is operated by the Educational Testing Service (ETS).

The Great Lakes East Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. It serves the states of Indiana, Michigan and Ohio. It is operated by Learning Point Associates.

Serving the states of Illinois and Wisconsin, the Great Lakes West Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education.

The Mid Atlantic Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. It serves the states of Delaware, Maryland, New Jersey, and Pennsylvania, and the District of Columbia.It is operated by the George Washington University.

The Mid-Continent Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. The center serves the states of Arkansas, Kansas, Missouri and Oklahoma. It is operated within the Public and Community Services Division of the College of Continuing Education of the University of Oklahoma.

The National Comprehensive Center for Teacher Quality (TQ Center)is one of 21 comprehensive centers funded by the U.S. Department of Education. It is operated by Learning Point Associates. Its partner organizations include the Education Commission of the States, ETS and Vanderbilt University.

The National High School Center is one of 21 comprehensive centers funded by the U.S. Department of Education. The National High School Center serves as the central source of information and expertise on high school improvement for the Regional Comprehensive Centers. It is operated by the American Institutes for Research.

The New England Comprehensive Center is one of 21 comprehensive centers funded by the U.S. Department of Education. It serves the six New England states. It is operated by RMC Research Corporation in partnership with the Education Alliance at Brown University, Providence, RI; the Education Development Center, Inc., Newton, MA; and Learning Innovations at WestEd, Woburn, MA.

The New York Comprehensive Center is one of 21 comprehensive centers funded by U.S. Department of Education. It serves the state of New York. It is operated by RMC Research Corporation in partnership with the Education Alliance at Brown University, Providence, RI; the Education Development Center, Inc. (EDC), Newton, MA; Learning Innovations at WestEd, Woburn, MA; and the United Federation of Teachers Teacher Center, New York, NY.